Ok, I assume you're referring to the mirror that shows the reflection of the insane women even after you've killed the two in the room. Is there something you're supposed to do to trigger it? Am I just a moron (don't answer that..)

Yes, made it to the room with 2 mirrors, killed a couple of insane lunatics, listened to the recording and nothing is happening.

Ok, I'm stuck at the same point in the Grout mansion, having solved the initial candle riddle and gotten the staircase to open up. How and where is the next trigger activated?

I'm looking for Tin Can Bill as part of the plaguestopper quest and can't find him. Is he in plain sight? I'm wondering if his being missing is some sort of glitch.