I've been a proponent of Kiva
for several years now. Kiva is a microfinance group that takes lending funds from folks like you and me and provides it interest-free to on-the-ground partners in impoverished areas who then manage loans to local people. The end result is that those folks are able to obtain funding for various projects at better terms than they'd get through a bank (if there's even such a thing as a bank where they're at, and if they could even hope to be approved).
At the end of a loan, you can either take your money back or re-lend it. (Defaults are very rare-- <1%.) It thus makes a good 'keeps on giving' charity as you can periodically put in small amounts and keep re-lending as time goes on. It's a cool feeling to put in $25 and see it help multiple people--and you can still (with 99% confidence) take it back out in the future.
I'm trying to participate more on GT since you were all so gracious hosting all of us OOers during the recent OOtage, and figured sharing Kiva was a good way to start. We have a Kiva group
going on over at OO that you are welcome to join in on, or feel free to create your own. I thought since we have a large cross-forum contingency that joining forces in one group would make sense.
Further, right now Kiva is running a free $25 to lend promotion for new members, where when you sign up, a rich-guy Kiva friend gives you $25 to lend. So far our group has lent $2600 and to my knowledge no loans have fallen through without being repaid.