I don't read comics nearly as much as I used to (the mainstream stuff largely passes me by), but I just finished the first TPB of the Big Trouble in Little China series by Eric Powell (The Goon), and really enjoyed it.
However, if there's one series I feel the need to tie people down and read, without a doubt, it's Saga
. Holy shit, it's absolutely fantastic storytelling/world-building/character creation, accompanied by some amazing artwork. If you pick it up and flip through the pages, it might look too weird (and decidedly not for kids), but there's magic in those pages that will work on you.
Do Not Miss SAGA!