I have to say I really miss the size of the 5, only because it was easier to use one handed. I could reach the upper left easily, and it just felt more comfortabLe to hold. As far as in pocket, the difference is barely noticeable. On the other hand, I really do like having a bigger screen and would hate to go back to a smaller size. I guess I have two years to figure which is more important.
This is exactly where I am. The larger screen is really fantastic, and I suspect it will lead me to start playing more games on it. But there's no way around the fact that it's overall a much less convenient size. On top of things like not fitting well in pants and being awkward even on a belt, the weight balance when you hold it in one hand is just a bit off. It's too top heavy or just too long IMHO, so it doesn't feel as secure in one hand as I'd like. And I'd say my hands are average to large size. I suspect the 6 would have been better for me, but I know myself and I'd always be wanting to try the larger one.