Online leagues here have met with disappointment in years past, but I played in the Quarter to Three league last year, and it made it through two seasons and was a lot of fun. We're having some trouble rounding people up this year, so I thought I'd cross-post.
Here's the link: http://www.quartertothree.com/game-talk/showthread.php?t=65929
Madden is very good this year. I think it suffers from some polish in the presentation and sound issues, but the gameplay is excellent. A lot of you already post on Qt3, so you know they're a bunch of likeminded, good guys who will play a good game of football. Anyway, check it out if you're interested.